Figure 1.
The rise in serum creatinine (Cr) is higher in Puumala virus (PUUV)-infected patients with severe acute kidney injury (AKI) compared to those with non-severe AKI.
The maximum white blood cell (WBC) count occurred several days before the peak Cr in PUUV-infected patients with severe AKI (a). PUUV-infected patients with severe AKI have greater proteinuria than those with non-severe AKI (b). Severe AKI is >3-fold rise in serum Cr during acute illness compared to a 6 month baseline. Illness day 1 is the first calendar day of reported fever. Symbols and error bars are mean±S.E.
Table 1.
Characteristics of study subjects with PUUV nephropathia epidemica.
Table 2.
Clinical laboratory indicators in study subjects with PUUV nephropathia epidemica.
Figure 2.
Maximum urine IL-6, plasma IL-6, and urine IL-8 concentrations are positively correlated with the degree of PUUV-induced AKI.
a) maximum urine IL-6 levels b) maximum plasma IL-6 levels c) maximum urine IL-8 levels d) maximum plasma IL-8 levels.
Figure 3.
Urinary sediment GATA-3 mRNA levels are elevated and T-bet mRNA levels are decreased during acute illness in PUUV-induced severe AKI.
Severe AKI is >3-fold rise in serum Cr during acute illness compared to a 6 month baseline. Illness day 1 is the first calendar day of reported fever. a) Urinary sediment CD3ε mRNA relative expression compared to 2 week baseline value b) Urinary sediment GATA-3 mRNA relative expression compared to 2 week baseline value c) Urinary sediment T-bet mRNA relative expression compared to 2 week baseline value. Symbols and error bars are mean±S.E.
Table 3.
Multivariate statistical models for acute kidney injury in study subjects with PUUV nephropathia epidemica.