Figure 1.
Markov diagram of health states and the possible transitions among them during each 1-month cycle.
Table 1.
Medical Resource Use and Costs Estimates ($, year 2009 values).
Table 2.
Base-Case Utilities.
Table 3.
Trial Data and Model Estimated Values.
Table 4.
Base Case Results for the Alternative Strategies for Cost, QALY Gained and ICER.
Figure 2.
Analysis of the cost effectiveness of the first-line strategies for GBM in the overall cohort and the 8 subgroups.
The x-axis represents the undiscounted 5-year quality-adjusted life-years (QALYs) for each strategy, and the y-axis represents the total undiscounted 5-year costs (in US dollars). The oblique line connects the RT strategy and the most cost-effective strategies; strategies above the straight lines were dominated or extended dominated.
Figure 3.
A tornado diagram of one-way uncertainty analyses in the overall cohort.
The graph shows the effects of the variables on net health benefit (in QALYs, with WTP = $11,034) between the RT and TMZ strategies. The width of the bars represents the range of the results when the variables are changed, as shown in Tables 1, 2, 3. The vertical dotted line represents the base-case results. The vertical line represents the base-case value for the net health benefit with WTP = $11,034. PFS: progression-free survival; OS: overall survival; HR: hazard ratio.
Figure 4.
The probabilistic results of the incremental cost-utility differences for GBM in the overall cohort and the 8 subgroups.
The TMZ strategy was compared to: (A) the RT strategy and (B) the NT strategy for a cohort of 1,000 GBM patients. The y-axis represents the incremental costs. The x-axis represents the incremental QALYs gained. Each ellipse represents the 95% confidence interval ellipse of the probabilistic results. The proportion of the ellipses found below the ICER threshold (the oblique lines) reflects the simulations in which the cost per additional QALY gained with the TMZ strategy was below the ICER threshold.
Figure 5.
The cost-effectiveness acceptability curves for the three first-line strategies for GBM in the overall cohort and the 8 subgroups.
The vertical axes represent the probabilities of cost effectiveness. The horizontal axes represent the willingness-to-pay thresholds to gain 1 additional quality-adjusted life-year (QALY). The bold vertical dashed and solid lines represent the thresholds for China and Shanghai City, respectively.