Figure 1.
Chromatograph of 177LuCl3 and 177Lu-DOTATATE in 50% Aqueous Acetonitrile (a); Stability of Labeled compound till 6th day post-labeling (b).
Figure 2.
SEM image showing morphology; and Size analysis using measurement software on TEM Image and Particle size analyzer for PLGA 50∶50 nanoparticles (a), (b) & (c) and PLGA 75∶25 nanoparticles (d), (e) & (f) respectively.
Figure 3.
SEM image and particle size distribution of PEG-coated (a) & (b) PLGA 50∶50 and (c) & (d) PLGA 75∶25 Nan particles.
Table 1.
Mean Particle Size of Nanospheres.
Table 2.
Mean Percentage Encapsulation of 177Lu-DOTATATE in Nanospheres.
Figure 4.
Cumulative percentage release 177Lu-DOTATATE from uncoated and PEG-coated (a) PLGA 50∶50 nanoparticles and (b) PLGA 75∶25 nanoparticles.
The bars represent standard deviation. (c) Total release over 21days.
Figure 5.
Distribution of 177Lu-DOTATATE (Group A); 177Lu-DOTATATE-PLGA nanoparticles (Group B); and 177Lu-DOTATATE-PLGA-PEG nanoparticles (Group C) in different organs over 24 h.
The bars represent standard deviation.
Figure 6.
Comparative distribution of radioactivity in (a) kidney and (b) liver of three groups of rats.
Figure 7.
Images of rats acquired at 4 h post-injection. A = Anterior, P = Posterior.
Figure 8.
Images of rats acquired at 24 h post-injection. A = Anterior, P = Posterior.
Figure 9.
Reduced aggregation is seen on TEM images of PEG-coated PLGA nanoparticles (b) as compared to uncoated nanoparticles (a).