Figure 1.
The level of CD15+ tumor-infiltrating neutrophils (TINs) in gastric adenocarcinoma surgical specimens shown by immunohistochemistry.
(A), (B), (E) and (F): High density of CD15+ TINs. (C), (D), (G) and (H): Low density of CD15+ TINs. Original magnification: A–D×200; E–H×400.
Table 1.
Relationship between CD15+TINs and clinicopathological features of gastric adenocarcinoma patients in the training group.
Figure 2.
The Kaplan–Meier survival analysis of gastric adenocarcinoma patients (n = 115) in the training group with a low density of CD15+ TINs (n = 57) and a high density of CD15+ TINs (n = 58).
Based on the median number of CD15+ TINs (21.60 cells/HPF) in the 115 cases, the patients were divided into two groups: high CD15+ TINs group (≧21.60 cells/HPF) and low CD15+ TINs group CD15+ TINs (<21.60 cells/HPF). The survival rate of patients with a high density of CD15+ infiltrating neutrophils was significantly lower than that of patients with a low density of CD15+ infiltrating neutrophils (Log rank test, p = 0.002).
Table 2.
Univariate and multivariate analysis of overall survival in gastric adenocarcinoma patients in the training group.
Figure 3.
The Kaplan–Meier survival analysis of gastric adenocarcinoma patients (n = 97) in the test group with a low density of CD15+ TINs (n = 52) and a high density of CD15+ TINs (n = 45).
The patients were divided into high CD15+ TINs group (≧21.60 cells/HPF) and low CD15+ TINs group (<21.60 cells/HPF) according to the median density of CD15+ TINs (21.60 cells/HPF), which was obtained from the training group. Log-rank test shows that the patients with the high density of CD15+ TINs showed significantly poorer prognosis than those with the low density of CD15+ TINs (p = 0.032).
Table 3.
Clinical characteristics of gastric adenocarcinoma patients in the training group and test group.