Table 1.
Characteristics of 147 patients with high-risk squamous cell cancer of the head and neck.
Figure 1.
An expression of PTEN in the tumor tissue.
A range of PTEN expression in the tumor tissue: A - high, B - low. Visible positive staining of the surrounding matrix in both specimens. Original magnification: 100×.
Figure 2.
Clinical outcome according to PTEN expression.
Loco-regional control (A), distant metastases-free survival (B), and freedom from secondary cancer (C), according to PTEN expression in 147 patients with high-risk HNSCC treated in p-CAIR trial.
Figure 3.
PTEN expression as a predictor of benefits from p-CAIR fractionation.
Loco-regional control (LRC), according to fractionation in subset of 147 patients from the p-CAIR trial used in the present study (A), LRC according to fractionation and expression of PTEN in subset of 147 patients from the p-CAIR trial used in the present study: HIGH PTEN expression (B), LOW PTEN expression (C).
Table 2.
Factors that significantly and independently affected LRC: results of a multivariate analysis.
Figure 4.
Loco-regional control in HNSCC according to most significant risk factors.
Loco-regional control according to the number of following risk factors: absence of HPV infection in tumor, low PTEN expression, neck node involvement, high EGFR expression, and high nm23 expression. The analysis was restricted to 123 patients from the p-CAIR trial with known HPV status and known status of the other 4 markers.