Table 1.
A summary table of blood pressure and hypertension susceptibility genes identified by using GWAS.
Figure 1.
An analysis flowchart of this study.
Figure 2.
Gene-based association tests based on p-values from the four conditional logistic regression models.
(A) model CLRN, (B) model CLRN,BMI, (C) model CLRC, and (D) model CLRC,BMI. In each figure, the vertical axis is the FDR-adjusted p-values (−log10 scale) of gene-based association tests, and the horizontal axis is cumulative physical position (Mb scale). The red reference line signifies pFDR = 10−3.
Figure 3.
Evaluation of the 17 differentially expressed genes in hypertension.
(A) Cluster analysis of transcriptional data from 12 pairs of patients with hypertension (HT) and normotensive controls (NC). (B) Principal component analysis (PCA) of transcriptional data from 12 pairs of patients with hypertension and normotensive controls), where the variation explained by the first two principal components (PC #1 and PC #2) is 39% and 13.1%.
Table 2.
Seventeen genes with differential allelic and transcriptional distributions identified by the TWNHS.
Table 3.
Replication analysis of the seventeen genes with differential allelic and transcriptional distributions in cases and controls.