Figure 1.
Metabolic paths identified until end metabolite synthesis in pyrimidine metabolism (00240) connected pathways starting from the reaction (R00978) catalyzed by the enzyme, dihydropyrimidine dehydrogenase (NADP+ [EC: 1.3.1.2], KEGG Orthologous Id: K00207).
Figure 2.
Flow diagram representing methodology implemented in UniDrug-Target server to identify potential pathogen-specific drug targets.
Figure 3.
UniDrug-Target architecture.
Table 1.
Sample analysis report of one of the pathogen-specific protein (gi:15607938) of M. tuberculosis to determine domain-level conserveness in low-matching sequences between pathogen-specific and non-pathogenic protein sequencesζ.
Figure 4.
UniDrug-Target predicted pocket forming residues (Table 2) of gi:15607942 (PDBID: 2VZZ).
Visualization through VMD (www.ks.uiuc.edu/Research/vmd/) showed that above residues forming a pocket. Pocket forming residues shown in the surface representation.
Table 2.
Identified pocket residues of pathogen-specific protein, gi:15607942, matching with residues forming similar pocket in nonpathogenic sequences of different organisms *.