Table 1.
Patients characteristics at inclusion.
Figure 1.
Correlation between estimated and measured by iohexol plasma clearance GFR.
Values estimated by CKD-Epi and aMDRD formulas are shown in the left and right panel respectively. Dot lines are identity lines; continuous lines are regression lines.
Figure 2.
Agreement between measured and estimated GFR values.
Bland-Altman plot of the difference between GFR estimated (eGFR) by the CKD-Epi (Upper panel) and by aMDRD (Lower panel) formulas and measured GFR (mGFR) vs. the mean of the two determinations. Straight line and dashed lines indicate mean difference and 95% limits of agreement, respectively.
Figure 3.
Absolute differences between measured and estimated GFR values vs baseline measured GFR.
The absolute differences significantly increase for both CKD-Epi (Upper panel) and aMDRD (Lower panel) formulas for increasing values of GFR. Continuous lines are regression lines.
Figure 4.
Relationship between GFR values ranked according to renal function.
Correlation between GFR measured by iohexol plasma clearance and GFR estimated by the CKD-Epi (Upper panels) and aMDRD (Lower panels) formulas in patients with baseline GFR< or ≥70 mL/min/1.73 m2 considered separately (Left and Right panels, respectively). Dot lines are identity lines; continuous lines are regression lines.
Table 2.
Performance of CKD-Epi and aMDRD equations in predicting GFR at inclusion in 111 ADPKD patients as a whole and ranked according to mGFR<70 (n = 45) and ≥70 (n = 66) mL/min/1.73 m2.
Table 3.
Measured and estimated one-year GFR changes vs. baseline in 71 ADPKD patients as a whole and ranked according to mGFR<70 (n = 25) and ≥70 (n = 46) mL/min/1.73 m2.
Figure 5.
Relationship between measured and estimated 1-year GFR changes.
Correlation between measured 1-year GFR changes vs. baseline and corresponding changes estimated by CKD-Epi (Left panel) and aMDRD (Right panel) formulas. Dot lines are identity lines; continuous lines are regression lines.
Figure 6.
Bland-Altman plots of measured and estimated 1-year changes.
Graphs show the agreement between estimated by CKD-Epi (Upper panel) or by aMDRD (Lower panel) formulas and corresponding measured 1-year GFR changes vs. baseline. Straight line and dashed lines indicate mean difference and 95% limits of agreement, respectively.
Figure 7.
Absolute differences between measured and estimated 1-year GFR changes vs baseline measured GFR.
The absolute differences between 1-year GFR changes for both CKD-Epi (Upper panel) and aMDRD (Lower panel) formulas significantly increase for increasing values of GFR. Continuous lines are regression lines.
Figure 8.
Relationship between 1-year GFR changes ranked according to renal function.
Correlation between measured 1-year GFR changes vs. baseline and corresponding changes estimated by CKD-Epi (Upper panels) and aMDRD (Lower panels) formulas in patients with baseline GFR< or ≥70 mL/min/1.73 m2 considered separately (Left and Right panels, respectively). Dot lines are identity lines; continuous lines are regression lines.