Table 1.
Demographic and histopathologic data for serum samples.
Figure 1.
Retrospective study design used to identify miRNA that could distinguish healthy controls (normal) from lung cancer patients.
Figure 2.
Differential expression of miRNA diffpair miR-15b/miR27-b in sera from healthy donors (normal) and from lung cancer patients (cancer).
Differential expression values were calculated as a difference of the Ct values for the two miRNAs. The threshold indicated by the horizontal line was selected to maximize the sum of sensitivity and specificity as described in data analysis. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) obtained using the differential expression of the 2 miRNA displayed as tables for the training set (on the right) and the test set (on the left).
Figure 3.
Receiver Operating Characteristic (ROC) plot for the diffpair miR-15b/miR27b from the test set.
Table 2.
Differential miRNA expression in sera from NSCLC patients (cancer) and healthy controls (normal) in test set.