Table 1.
List of inflammatory factors evaluated in CSF and serum samples.
Figure 1.
Serum SDF-1 is elevated in boys with cerebral ALD.
SDF-1 levels were determined by ELISA. Boxes show min and max, and the bar is at the mean. A Student's unpaired t-test calculated p-value shown.
Figure 2.
CSF inflammatory cytokines are elevated in boys with cerebral ALD.
CSF cytokines were evaluated using a Lumunix system and SDF-1 by ELISA. Boxes show min and max, and the bar is at the mean. A Student's unpaired t-test calculated p-values shown.
Figure 3.
Correlation of CSF MCP-1 levels and chitotriosidase activity.
Regression analysis was performed using CSF MCP-1 levels and CSF chitotriosidase activity as described by Orchard et al [10]. Statistical analysis was performed using Prism software.
Figure 4.
Correlation of serum SDF-1 levels and Loes MRI severity score.
Regression analysis was performed using serum SDF-1 levels and each patient's pretransplant Loes score using Prism software.
Figure 5.
Correlation of CSF inflammatory cytokine levels and Loes MRI severity score.
Regression analysis was performed using the previously determined CSF cytokine levels and each patient's pretransplant Loes score using Prism software.
Figure 6.
Elevated levels of CSF total protein correlate to IL-8, MCP-1, and Loes MRI severity score.
CSF total protein levels were taken from the patients' medical record. Boxes show min and max, and the bar is at the mean. Regression analysis was performed using the previously determined CSF cytokine levels for IL-8 and MCP-1 as well as each patient's pretransplant Loes score using Prism software.