Table 1.
Baseline characteristics Patients and Controls.
Figure 1.
Differential gene expression in patients versus controls validated by qPCR in the discovery set.
The X-axis depicts the relative fold changes in gene expression in the patients compared to controls. For each gene the first (pale grey) bar depicts the fold change in microarray expression levels, the second (mid grey) bar shows the change in microarray intensities and the final (black) bar shows the qPCR 2exp ΔΔCT change. Values are given as mean + SD. A relative fold change of ≤1 or −1 indicates no effect.
Figure 2.
Differential gene expression in controls due to medication.
The x-axis the average change in expression following the use of statins and aspirin depicted as 2expΔΔCT. Values are given as mean + SD. A relative fold change of ≤1 or −1 indicates no effect. For ADRB2 and ABCG1 the changes were significant; p = 0.04 and p<0.001 respectively.
Figure 3.
Differential gene expression in patients versus controls determined qPCR in the replication set.
The X-axis depicts the relative fold changes in gene expression in the patients compared to controls. depicted as the qPCR 2exp ΔΔCT change. Values are given as mean + SD. A relative fold change of ≤1 or −1 indicates no effect.