Table 1.
Observational battery average results of all mice treated with scopolamine or vehicle.
Figure 1.
Significant differences in rota rod performance, in scopolamine-treated vs vehicle-treated groups (P≤0.05) are shown. Numbers are representing seconds of remaining on the revolving rod.
Figure 2.
Significantly higher latencies and longer pathlengths were observed in the scopolamine-treated animals (A,B). Correct decisions to reach the goal box were higher in vehicle-treated and trained mice (C) and the number of successful entries into the goal box during training days was significantly higher in the vehicle-treated and trained mice (D). At the probe trial latencies were significantly lower in the vehicle-treated and trained mice (E).
Figure 3.
The M1 receptor complex levels were significantly higher in scopolamine-treated groups.
Figure 4.
Western blot results of Nic 7.
Nic7 complex levels were significantly higher in scopolamine-treated groups. Significant differences were also observed when scopolamine-treated trained and untrained mice were compared.
Figure 5.
Western blot results of Nic 4.
Although a trend was suggested no significant differences between groups were observed.
Figure 6.
NR1 containing NMDA complex levels (band 1) were significantly increased in the scopolamine-treated trained group vs the vehicle-treated and trained panel (A). Band 2 (B) was not significantly different between groups.
Figure 7.
The membrane used for immunoblotting was stained by Coomassie blue R-350. Adaequate loading was shown.
Figure 8.
(A) The significant correlation between Nic4 and M1 complex levels as well as (B) the significant correlation between NR1 (band 2) and Nic7 is demonstrated.
Figure 9.
The multiple T-maze is a landmaze paradigm testing spatial memory. Animals with food deprivation search for food that is provided in the goal box.