Figure 1.
SN outlined on a TH-immunostained transverse slice with 2× magnification.
Typical pictures were taken on the left (A) and right (B) side of the same slice separately with SN and ventral tegmental area (VTA) outlined. SN lies ventral and lateral to VTA. The 3rd cranial nerve fibers are indicated by arrows. Scale bar: 1 cm.
Figure 2.
Representative autoradiograms of [3H] WIN 35,428 and [3H] DTBZ.
[3H] WIN 35,428 binding to DAT (top row) (A–D), [3H] DTBZ binding to VMAT2 (bottom row) (E–H) in coronal sections from the injected side of control (A and E) and MPTP-treated monkeys (B–D and F–H). Images represent total binding, according to the pseudo-color bar on the right side of each image. Scale bar: 0.5 cm.
Figure 3.
Relationship between VMAT2 (A) or DAT (B) Bmax and residual SNpc TH-ir neurons.
The value for each monkey was expressed as the ratio of the injected side to the control side in 13 monkeys.
Figure 4.
Relationship between VMAT2 (A) or DAT (B) Bmax and residual striatal dopamine content.
The values for each monkey were expressed as the ratio of the injected side to the contralateral side, and the line is the linear fit of the data.
Figure 5.
Relationship between striatal VMAT2 and DAT Bmax in 14 monkeys.
The value for each monkey was expressed as the ratio of the injected side to the control side, and the line is the linear fit of the data. The r value reflects the Spearman's correlation coefficient value obtained in striatum.