Figure 1.
Overall view of the metabolite concentration and gene expression correlation at increasing network distances.
In Figure 1c the numbers in brackets on the horizontal axis indicate the average number of unique genes at each network distance.
Table 1.
Minimum set cover solution summary statistics for each stress condition.
Figure 2.
Minimum set network visualization for all stress conditions combined, and for each separately.
Green circles are minimum set metabolites and orange squares are hub reactions. The node size reflects how many stress conditions each node is observed. Small red circles and orange squares are metabolites which can be produced by a significant path and reactions respectively. Blue nodes are metabolites which are included in a path included within the minimum set, but have no significant path terminating at that metabolites. Gray nodes are not included in any path.
Figure 3.
(left column) Clustered gene expression profiles (z-scaled) for each hub reaction; (center column) Metabolite profiles (z-scaled) for all metabolites in the minimum sets; (right column) A correlation heat map correlating the mean hub expression cluster profiles with each metabolite profile, green indicates strong positive correlation and red indicates strong negative correlation.