Figure 1.
The flowchart of selection of studies and specific reasons for exclusion from the meta-analysis.
Table 1.
Detailed characteristics of eligible studies considered in the meta-analysis.
Figure 2.
Meta-analysis for the overall association between the A-6G polymorphism and hypertension under the dominant genetic model.
Figure 2 shows that the -6A allele carrier (AA+AG) can reduce the risk of hypertension compared to the homozygous GG genotype carriers.
Table 2.
Sample size, the distribution of A-6G genotypes and allele frequencies, and P-values of HWE.
Figure 3.
Meta-analysis for the association between the A-6G polymorphism and hypertension under allele comparison (A vs. G) in the subgroup by sex.
Figure 3a shows that the A-6G polymorphism is not associated with hypertension in men. Figure 3b shows that the -6 A allele carrier can reduce the risk of hypertension in women compared to the -6G allele carrier.
Table 3.
The characteristics of all included studies for the A-6G polymorphism in the sex-specific subgroup analysis.
Figure 4.
Meta-analysis for the overall association between the A-20C polymorphism and hypertension under various genetic contrasts.
Figure 4a shows that the C allele carrier can increase the risk of hypertension compared to the A allele carrier. Figure 4b shows that the homozygous CC genotype carriers can increase the risk of hypertension compared to the A allele carrier (CA+AA).
Table 4.
Sample size, the distribution of A-20C genotypes and allele frequencies, and P-values of HWE.
Figure 5.
Begg's funnel plot analysis to detect publication bias.
Figure 5a shows the funnel plot for allele comparison (A vs. G) of the A-6G polymorphism. Figure 5b shows the funnel plot for allele comparison (C vs. A) of the A-20C polymorphism.