Table 1.
Inclusion and exclusion criteria of the Leipzig (LIFE) Heart Study.
Table 2.
Numbers of subjects recruited in several cohorts and composite phenotypes.
Figure 1.
Angiographic findings of subjects with suspected CAD (cohort 1).
Arrangement in age strata beginning with 18–45 years followed by 10-years intervals for men and women, separately. Coronary angiograms were interpreted as no CAD when angiographically normal coronary arteries were found, the presence of wall irregularities (WI) was interpreted as intermediate coronary atherosclerosis (CAD<50%). Stenoses with ≥50% luminal reduction were rated as obstructive CAD and assessed as 1-, 2- or 3-vessel disease (1VD, 2VD, 3VD). For comparison, representative results of the American College of Cardiology National Data Registry (NCDR CathPCI Reg.) are shown including patients with elective coronary angiography for suspected coronary artery disease [21].
Table 3.
Characteristics of male subjects.
Table 4.
Characteristics of female subjects.
Figure 2.
Case-control based association and within-CAD association at chromosome 9p21a.
abased on haplotype block consisting of 4 SNPs, myocardial infarction defined as elevated troponin and culprit coronary lesion at time of recruitment (cohort 1 and 2) or recollected myocardial infarction (cohort 3), stable CAD defined as obstructive CAD, normal troponin level at time of recruitment and no recollected myocardial infarction (cohort 1 and 3).
Table 5.
Case-control based association of chromosome 9p21 with CAD.
Table 6.
Within CAD association of chromosome 9p21 with subcategories of CAD.