Table 1.
Demographic and health characteristics of study participants in the two populations.
Table 2.
Association of SNPs with type 2 diabetes in the UKADS and DGP study populations.
Figure 1.
Association of 16 SNPs with fasting glucose in South Asians and Europeans.
South Asians from the current study (filled diamonds, n = 1163) and Europeans from the MAGIC [1] study (unfilled diamonds, n≤76,558). acGRS = allele count GRS, wGRS = weighted GRS. ES = effect size, the per-risk allele change in fasting glucose (mmol/l). The GCK rs1799884 SNP was used as a proxy for the rs4607517 variant reported in Dupuis et al [1] (r2 = 1.0 in CEU HapMap samples).
Figure 2.
Association of 16 SNPs with type 2 diabetes in South Asians and Europeans.
South Asians from the current study (filled diamonds, n = 3262) and Europeans from the MAGIC [1] study (unfilled diamonds, n≤127,667). acGRS = allele count GRS, wGRS = weighted GRS. ES = effect size, the per-risk allele odds ratio. The GCK rs1799884 SNP was used as a proxy for the rs4607517 variant reported in Dupuis et al [1] (r2 = 1.0 in CEU HapMap samples).
Table 3.
Statistical power for fasting glucose and type 2 diabetes analyses in the combined UKADS/DGP study population.