Table 1.
Patient characteristics and baseline values of outcome measures broken by patient group.
Table 2.
Statistical t- (df = 9) and (unilateral) p-values of the calculated planned comparisons broken by patient group and as functions of outcome measure and time point.
Figure 1.
Normalized tinnitus loudness changes relative to baseline at four time points after training completion for both patient groups. White bars represent the low tinnitus frequency (≤8 kHz) group, black bars represent the high tinnitus frequency (>8 kHz) group. Asterisks denote significant changes, the error bars denote standard errors of the mean. Positive values indicate aggravation, and negative values indicate alleviation.
Figure 2.
Tinnitus-related distress ratios.
Normalized tinnitus-related distress changes relative to baseline at four time points after training completion for both patient groups (arrangement according to Figure 1).
Figure 3.
N1m and ASSR source strength ratios.
Normalized N1m and auditory steady-state response (ASSR) changes relative to baseline at three time points after training completion for the patient group characterized by tinnitus frequencies ≤8 kHz. White bars represent N1m source strength, black bars represent ASSR source strength. Asterisks denote significant changes, the error bars denote standard errors of the mean. Positive values indicate increment, and negative values indicate decrement. Please note that for the patient group characterized by tinnitus frequencies >8 kHz auditory evoked fields are not available due to technical limitations of the MEG sound delivery system (limit = 8 kHz).
Figure 4.
Exemplary frequency spectra of original (red) and modified (i.e. flattened and notched) (blue) music pieces. Here, the notch is centered at 7100 Hz.
Figure 5.
A Example of a 30 Hz low-pass filtered auditory evoked field exhibiting a clear N1m response peaking 0.1 s after stimulus onset. B Example of a contour plot corresponding to the 0.01 s time interval prior to the N1m peak shown in A. The plot displays clear dipolar patterns over left and right hemispheres.