Figure 1.
Lung clearance index (LCI) plotted against age (weeks) in infants diagnosed with cystic fibrosis following newborn screening.
Infants with air trapping are shown in closed circles.
Table 1.
Anthropometric and clinical characteristics at the time of assessment.
Figure 2.
Lung clearance index (LCI; upper panel) and the second moment ratio (M2/M0; lower panel) difference with the presence and absence of bronchiectasis (n = 13 with and n = 36 without bronchiectasis) and air trapping (n = 24 with and n = 25 without air trapping) in infants with cystic fibrosis.
Data are presented as box and whisker plots representing the 25th and 75th centiles and 10th and 90th centiles respectively. There were no differences in LCI between those infant with (grey box) and without (white box) lung damage while M2/M0 was significantly increased (p = 0.049) in those infants and young children with air trapping present on chest CT.
Figure 3.
Changes in the lung clearance index (LCI; panel A) and the first (M1/M0; panel B) and second moment ratios (M2/M0; panel C) with the increasing extent of air trapping.
Increasing extent of air trapping was associated with an increased LCI (r = 0.31 p = 0.03) and M2/M0 (r = 0.40; p<0.005) but not M1/M0 (r = 0.28; p = 0.051).
Table 2.
Multivariate relationships between ventilation inhomogeneity and the extent of air trapping.