Table 1.
Differently expressed genes identified by BAM.
Table 2.
Differently expressed gene ontology categories in KBD vs. control.
Table 3.
Selected pathways significantly up-regulated in KBD vs. control.
Figure 1.
Histogram showing the expression values of the selected 8 genes measured by microarray and qRT-PCR.
* indicates p<0.05 and † indicates p<0.01, calculated by paired t test.
Figure 2.
Characteristics of Kashin-Beck disease (KBD).
A&B, images of left hand(A, left male patient aged 55 years) and knees (B, left female patient aged 44 years, middle male patient aged 42 years, right female patient aged 49 years) from representative patients with grade II or III KBD; C, radiographic images of left and right hands of a KBD patient exhibiting shortened phalanges, enlarged bone ends of phalanges, and narrowed joint space; D, radiographic images of left and right knees of a KBD patient exhibiting widened and narrowed joint space; E–G, hematoxylin and eosin staining of adult articular cartilage from a healthy subject (E) and two patients with grade II (F) or III (G) KBD (original magnification×100).
Table 4.
KBD-control sample pairs used for microarray and qRT-PCR.