Table 1.
Demographics and clinical findings.
Figure 1.
Within-group maps of the left DLPFC-FC in MCI and healthy control groups.
The voxels with hot color represent DLPFC positive functional connectivity, and the voxels with cold color represent DLPFC negative functional connectivity. The statistical threshold was set at P<0.01 and cluster size > = 405 mm3, which corresponded to a corrected P<0.05. Left is the left.
Figure 2.
Within-group maps of the right DLPFC-FC in MCI and healthy control groups.
The voxels with hot color represent DLPFC positive functional connectivity, and the voxels with cold color represent DLPFC negative functional connectivity. The statistical threshold was set at P<0.01 and cluster size > = 405 mm3, which corresponded to a corrected P<0.05. Left is the left.
Figure 3.
DLPFC-FC asymmetry of Left vs. Right (hot color) and Right vs. Left (cold color) in healthy controls (Up), and DLPFC-FC asymmetry of Left vs. Right (hot color) and Right vs. Left (cold color) in MCI patients (Down).
The threshold was set at p<0.01 with cluster size > = 216 mm3, which corresponded to a corrected threshold of p<0.05. Left is the left.
Figure 4.
Regions showing significant differences in functional connectivity to the left DLPFC (Up) and right DLPFC (Down) between MCI patients and healthy controls (with GM correction).
For the details of the regions, see Table 4 and Table 5. Areas in hot color indicate brain regions with significantly decreased functional connectivity with the left/right DLPFC in MCI patients compared to healthy controls. Areas in cold color indicate brain regions with significantly increased functional connectivity with the left/right DLPFC in MCI patients compared to healthy controls. The threshold was set at p<0.01 with cluster size > = 216 mm3, which corresponded to a corrected threshold of p<0.05. Of note, we showed the two-sample t-test results were attained within a corresponding mask by combining the one sample t-test maps of the two groups (Figure 1 and Figure 2). Left is the left.
Table 2.
Regions showing the group differences in the left DLPFC-FC (without GM correction).
Table 3.
Regions showing the group differences in the right DLPFC-FC (without GM correction).
Figure 5.
Regions showing significant group differences in the left lateralized (Up) and right lateralized (Down) DLPFC-FC asymmetry.
Areas in hot color indicate significant decreased lateralized DLPFC-FC asymmetry, and areas in cold color indicate significant increased lateralized DLPFC-FC asymmetry in MCI patients compared to healthy controls. The threshold was set at p<0.01 with cluster size > = 162 mm3, which corresponded to a corrected threshold of p<0.05. Left is the left.
Figure 6.
Scatter plots of the association in MCI group between the connectivity of the left DLPFC with a cluster in the left thalamus (A), the connectivity of the right DLPFC with a cluster in the right IPL (B) and the neuropsychological scores (including MMSE, CDT, CVLT) (without GM correction).
The two connections were found to be significantly decreased in MCI patients as compared to healthy controls.
Table 4.
Regions showing the group differences in the left DLPFC-FC (with GM correction).
Table 5.
Regions showing the group differences in the right DLPFC-FC (with GM correction).