Figure 1.
Flow chart detailing the selection process for articles included in the meta-analysis.
Figure 2.
Global skin colour distribution of native populations.
The colours on the map are based on the 36-tone chromatic scale devised by Austrian anthropologist Felix von Luschan to assess the unexposed skin of human populations. The higher numbers represent darker skin colour. Original data compiled by Biasutti 1941.
Table 1.
Genotype of each mouse strain for five pigment associated genes.
Figure 3.
Graphical representation of the human CCT meta-analysis results.
(A) Mean CCT of each ethnic group. Colours indicate tone of skin pigmentation according to the chart devised by Biasutti, 1941 (see Figure 1) (B) Mean CCT of the Dark Skin (524.6±33.6 µm, n = 16,472) and Light Skin (548.4±34.1 µm, n = 14,152) groups based on the skin colour of the ethnic groups in Figure 1A. There was a significant difference between the groups (p<0.001).
Table 2.
Characteristics of human cohorts.
Table 3.
Mean CCT for each ethnic group assessed in meta-analysis.
Figure 4.
Graphical representation of CCT measurements conducted on the inbred mouse strains.
(A) Mean CCT and coat colour of the each individual strain. There was a significant difference in mean CCT of each strain (p<0.001). The colours of the bars represent the coat pigmentation of the animals. Error bars indicate standard deviation. (B) Mean CCT of the Pigment (78.3±8.8 µm, n = 53) and Albino (83.5±11.1 µm, n = 79) groups based on the coat colour of the animals in Figure 3A. Error bars indicate standard deviation. There was a significant difference between the groups (p = 0.008).
Table 4.
Coat colour and mean CCT of each inbred mouse strain.
Table 5.
Mean CCT values for each genotype of the five pigment associated genes.