Table 1.
Distribution of age, sex and histology by EBV status in Chinese cHL patients.
Table 2.
Distribution of age, sex and histology by EBV status in Dutch cHL patients.
Table 3.
Differences in subtype distribution in Chinese and Dutch cHL patients.
Figure 1.
Age distribution of Dutch and Chinese cHL patients in consecutive 10-year intervals.
Age distribution is shown for 157 patients from Northern regions of China (black) and 515 patients from the Northern part of the Netherlands (grey). The two curves exhibit a somewhat similar trend with significant differences at the first, second, eighth and ninth decade (* = p<0.01, ** = p<0.001) between the Chinese and the Dutch population (6% vs. 1%, 22% vs. 12%, 1% vs. 7% and 0% vs. 3% respectively). The Chinese population has more patients among the first three decades as compared to the Dutch population, both having the highest peak in the third decade. The Chinese population does not show a second incidence peak at around 60 years.
Figure 2.
Age distribution of Dutch and Chinese cHL patients stratified by EBV status.
A represents the comparison of the age distribution in the two EBV+ cHL subpopulations. Chinese EBV+ cHL patients (black) exhibited a significant single peak in the first and second decade with a maximum percentage of 26% (* = p<0.01). In contrast, Dutch EBV+ cHL patients (grey) demonstrated a clear bimodal age distribution pattern with two peaks occurring in the third and seventh decade respectively with a similar incidence for both peaks (17% and 18%). B shows the age distribution curve of the EBV- cHL patients. There is a single incidence peak in the third decade for both populations, which is more pronounced in the Chinese population (39% vs. 27%).
Table 4.
Differences in age distribution in Chinese and Dutch cHL patients.