Table 1.
Characteristics of the study population.
Table 2.
Characteristics of NINJ2 haplotype tagging SNPs.
Table 3.
NINJ2 SNP analysis by genotype for dementia patients and controls.
Table 4.
NINJ2 SNP analysis by APOE e4 status for Alzheimer's disease patients and controls.
Figure 1.
NINJ2 linkage disequilibrium plot.
This plot was generated by Haploview program using the modified Gabriel et al. algorithm using data from this study. Five common haplotype (frequency ≥0.05) were identified and formed one block. The SNP name, e.g., SNP1, SNP2, etc., indicated five htSNP genotyped in this study. The level of pair-wise D', which indicated the degree of linkage disequilibrium between two SNPs, was shown in the linkage disequilibrium structure in red.
Table 5.
ORs between NINJ2 haplotypes and the risk of dementia.
Table 6.
Interaction between HAP2 and hyperlipidemia on AD risk.
Figure 2.
Postulated pathway of NINJ2 and mediators involved in the formation of dementia.
Solid lines indicated pathways have been well documented; dotted lines indicated speculated pathway. NFT denotes neurofibrillar tangle. Aβ denotes beta amyloid.