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Figure 1.

Cross sectional schematic of a solid tumor that shows the three different regions of a solid tumor, IFP distribution, drug concentration and filtration distribution from blood vessels.

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Figure 2.

Capillary microcirculation schematic and different types of pressure.

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Figure 3.

Two types of boundary conditions at the outer edge of the tissue.

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Table 1.

Material properties used in numerical simulations, as taken from [13].

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Figure 4.

Interstitial velocity distribution in a 1 cm radius tumor, different values of , Eq. (16).

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Figure 5.

Dimensionless interstitial pressure distribution in the same tumor, different values of .

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Figure 6.

Interstitial pressure distribution in the same tumor ().

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Figure 7.

Three dimensional plot of Fig. 6, dimensionless interstitial pressure distribution, in the same tumor ().

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Figure 8.

Comparison of the current paper with experimental data (mammary adenocarcinoma s.c.) by Boucher et al. [15].

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Figure 9.

Interstitial velocity distribution in a 1.4 cm radius tumor and normal tissue.

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Figure 10.

Interstitial pressure distribution in a 1.4 cm radius tumor and normal tissue.

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Figure 11.

Interstitial pressure distribution in a 1 cm radius tumor, as a function of the dimensionless radius for different necrotic radii.

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Figure 12.

Interstitial pressure distribution at the center of a 1 cm radius tumor, as a function of the dimensionless necrotic radius.

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Figure 13.

Interstitial pressure distribution at the center of different tumors, as a function of the dimensionless necrotic radius.

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Figure 14.

Interstitial pressure distribution in a 0.5 cm radius tumor, as a function of the dimensionless radius for different necrotic radii.

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Figure 15.

Interstitial pressure distribution in a 0.25 cm radius tumor, as a function of the dimensionless radius for different necrotic radii.

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Figure 16.

Interstitial pressure distribution in a 0.1 cm radius tumor, as a function of the dimensionless radius for different necrotic radii.

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