Table 1.
Clinical characteristics of the study participants.
Table 2.
Number of genes up- and down-regulated in each pairwise comparison.
Figure 1.
Heat map of the top 10 genes differentially up- and down-regulated for the three pairwise comparisons.
The samples and genes are illustrated in columns and rows, respectively. Red and green represent high and low expression, respectively. The full names and biological processes related with these genes are provided in Tables S4, S5, and S6.
Figure 2.
Cardiovascular functions linked to up-regulated genes in EAT compared to MAT.
ACSL1, Acyl-CoA synthetase long-chain family member 1; ADORA1, adenosine A1 receptor; HSD17B1, hydroxysteroid (17-beta) dehydrogenase 1; MGP, matrix Gla protein; NMB, neuromedin B; PTGDS, prostaglandin D2 synthase; SERPINA5, serpin peptidase inhibitor -clade A (alpha-1 antiproteinase, antitrypsin)- member 5; and SOX9, SRY (sex determining region Y)-box 9. *Interaction with itself. →Acts on.
Figure 3.
Cardiovascular functions linked to up- (red) and down-regulated (green) genes in EAT compared to SAT.
ACTG2, actin, gamma 2, smooth muscle, enteric; ADRA2A, adrenergic, alpha-2A-, receptor; AMPH amphiphysin; BCHE, butyrylcholinesterase; C6, complement component 6; CBS, cystathionine-beta-synthase; CNTNAP2, contactin associated protein-like 2; COL3A1, collagen, type III, alpha 1; COL12A1, collagen, type XII, alpha 1; CTSG, cathepsin G; CXCR4, chemokine (C-X-C motif) receptor 4; FRAS1, Fraser syndrome 1; MAOB, monoamine oxidase B; MARCKSL1, MARCKS-like 1; MYH11, myosin, heavy chain 11, smooth muscle; NOX4, NADPH oxidase 4; NTRK2, neurotrophic tyrosine kinase, receptor, type 2; PAMR1, peptidase domain containing associated with muscle regeneration 1; PDE1A, phosphodiesterase 1A calmodulin-dependent; RARB, retinoic acid receptor beta; SEMA3C, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; and SERPINE2, serpin peptidase inhibitor clade E (nexin, plasminogen activator inhibitor type 1), member 2. *Interaction with itself.
Figure 4.
Comparison of fold changes for ADORA1, ADRA2A, LIPE, and PTGDS.
EAT vs MAT (A), EAT vs SAT (B) and MAT vs SAT (C). The red bars represent the fold changes obtained by microarrays. The green and violet bars represent the fold changes obtained by qPCR for the microarrays and qPCR subjects, respectively. †Significant in the microarray experiment. *p<0.05, **p<0.001, and ***p<0.0001.