Table 1.
Demographic and clinical characteristics of subjects with RIS.
Figure 1.
T2-weighted lesion probability maps in RIS and RRMS.
The color overlay shows the probability of each voxel containing a lesion in each group. The color bar denotes the probability range. Background image is the MNI standard brain. In both groups, the areas with high probability of containing lesions were similar, mainly involving the superior and posterior regions of the corona radiata, the superior and inferior longitudinal fascicle and the body of the corpus callosum, with similar maximum peaks of lesion occurrence (RIS: 48%, RRMS: 54%). See text for abbreviations.
Figure 2.
Brain volumes in HC, RIS and RRMS.
Box plots comparing the brain volumes of HC (left), RIS subjects (center) and RRMS patients (right). Values are relative to NBV (left), NWMV (center) and NCV (right). Note the presence of similarly low values of brain volume in RIS subjects and RRMS patients with respect to HC. See text for abbreviations.
Figure 3.
Box plots comparing the MTr measures of HC (left), RIS subjects (center) and RRMS patients (right). Values are relative to whole brain-MTr (top left), lesional-MTr (top right), NAWM-MTr (bottom left) and cortical-MTr (bottom right). Note the differences between the three groups, with generally higher MTr values in RIS subjects than in RRMS patients. See text for abbreviations.
Figure 4.
Brain voxelwise MTr comparison between RIS and RRMS.
Red voxels show regions with significantly (p<0.05, cluster-corrected for multiple comparisons) lower MTr values in RRMS than in RIS. On smaller brains at the bottom right of each image, red shows the brain regions of the Harvard-Oxford GM atlas and DTI-based WM anatomy atlas corresponding to significant clusters. Background image is the MNI standard brain. Significant brain regions included the superior corona radiata, the body of corpus callosum and the inferior fronto-occipital fascicle (top-left image in coronal orientation); the paracingulate and cingulate gyri (top-right image in sagittal orientation); the inferior longitudinal fascicle, the planum temporale and the genu of corpus callosum (bottom-left image in axial orientation), the superior corona radiata and the paracingulate and cingulate gyri (bottom-center image in axial orientation); and the superior frontal, post- and precentral gyri (bottom-right image in axial orientation). See text for abbreviations.
Table 2.
Brain regions of the grey and white matter where RIS showed higher MTr than RRMS.
Figure 5.
Logistic regression analysis: probability for RIS to be HC or RRMS.
Panel A shows the distribution of subjects according to their NBV and lesional-WM MTr. HC are in blu, RIS subjects in red, and RRMS patients in green. Lesional-MTr values were calculated in RIS subjects and RRMS patients from T2-W lesional WM regions. MTr values in the WM of HC were calculated from areas homologous to those of the WM lesions of the RIS and RRMS. The black line separates the subjects with a probability of being a RRMS patient below and above 50%, according to the coefficients estimated by the penalized logistic model. The histogram of probability to be RRMS, as estimated according to the penalized logistic model including NBV and lesional-MTr as independent predictors, is reported in panel B. See text for further details.