Figure 1.
Schematic illustration of the information-based similarity index method.
(A) The mapping procedure for a n-tuple binary symbolic sequence (here n = 6 for illustrative purposes) from part of an interbeat interval time series. (B) Rank-order comparison of two interbeat interval time series from the two healthy subjects, using 6-tuple binary symbolic mapping. In this case, frequencies of 26 = 64 6-tuple symbolic patterns were determined and ranked accordingly. For each 6-tuple symbolic sequence (black dot), its rank in subject A is plotted against its rank in subject B. The dashed diagonal line indicates the case where the rank order of 6-tuple symbolic sequence for both subjects is identical.
Table 1.
Heart rate variability profile according to β1-adrenergic receptor Ser49Gly genotype.
Table 2.
Heart rate variability profile according to β2-adrenergic receptor Gln27Glu genotype.
Table 3.
Heart rate variability profile according to β2-adrenergic receptor Arg16Gly genotype.
Figure 2.
Unsupervised, hierarchical cluster tree of subjects according to the pairwise dissimilarity matrix among heart rate dynamics using an information-based similarity index method.
Dissimilarity matrix data were visualized and clustered by a generalized association plot algorithm [58]. The bars on the left indicate the β-adrenergic receptor (β-AR) gene polymorphisms rs1801252 (green: homozygous Ser49 carriers; blue: Gly16 allele carriers; red: unknown genotype), rs1042713 (green: homozygous Arg16 carriers; blue: Gly16 allele carriers) and rs1042714 (green: homozygous Gln27 carriers; blue: Glu27 allele carriers).
Table 4.
Genotype and standard heart rate variability characteristics according to two major clusters by a generalized association plot.