Table 1.
Characteristics of Serum and Gene groups.
Figure 1.
Elevated serum levels of total, apoptotic and necrotic cell death markers in patients with hepatic inflammation and advanced fibrosis.
The serum of 143 alcoholic patients were used to evaluate the circulating levels of total CK18 (M65® ELISA) and the caspases-generated CK18 fragment (M30 Apoptosense® ELISA). Results were expressed as median (25th, 75th percentile) in function to: (A) hepatic inflammation (A1) and (B) advanced fibrosis (F3/4).
Table 2.
Correlation between circulating levels of total, apoptotic and necrotic cell death markers and hepatic inflammation, Mallory-Denk bodies, ballooning and fibrosis in 143 alcoholic patients.
Table 3.
Correlation between hepatic TGFβ, TNFα and Fas-L gene expression and circulating levels of total, apoptotic and necrotic cell death markers in 24 alcoholic patients.
Table 4.
Univariate analysis of the 143 alcoholic patients according to the severity of liver disease.
Table 5.
Multivariate analysis for the prediction of the severity of liver disease.
Figure 2.
Levels of total, apoptotic and necrotic cells death markers for diagnosis of advanced fibrosis (F≥3) in 143 alcoholic patients.
The area under the ROC curves are shown for the performance of the total (CK18 total), apoptotic (CK18 fragment) and necrotic (CK18 total-fragment) cell death markers for predicting advanced fibrosis (F≥3).
Table 6.
Total, apoptotic and necrotic cell death marker levels for prediction of severe fibrosis (F≥3) (n = 143).