Table 1.
Designs and definitions for the simulation.
Table 2.
Definitions and interpretations of IIV formulae.
Table 3.
Means and SDs () for IIV definitions; these values are the actual sample values from the observed data and were used as “population parameters” for simulations.
Table 4.
Effect size estimates for IIV definitions, and total scores.
Table 5.
Correlations between observed values of the IIV formulations and total scores by diagnostic group from their baseline visits.
Figure 1.
Mean effect sizes based on 500 replications of simulating 500 “observations” for the nine IIV formulations outlined in the text.
Reference effect size (ES) values are shown giving the value obtained from the observed data for the total test score (flat lines) (Figure 1A: N vs MCI; Figure 1B: MCI vs AD).
Table 6.
Statistical explanatory power of within-test IIV (CV) at baseline for change in CDR Sum of Boxes at 12 and 24 months, based on observed data.