Figure 1.
Traditional Non-Volumetric Measurements do not Adequately Describe Residual Enhancement in Surgical Resection Cavities.
A) This schematic resection cavity has residual rim enhancement in gray. RECIST criteria measurement ‘A’ or ‘a’ or ‘b’ or Macdonald criteria measurement ‘A*B’ or ‘a*b’ would not adequately describe residual tumor volume and additional tumor growth around the rim or collapse of the resection cavity may be over- or under-interpreted. B) Differences in axial slice acquisition also impact measurements made by traditional criteria more than volumentric measurements. One scan could obtain axial slice ‘c’ with enhancing tumor measurement ‘x’ but a subsequent scan in the same patient could obtain axial slice ‘d’, causing an incorrect assessment of tumor response.
Figure 2.
Automated Assessment of Enhancing Tumor Volume.
A) T1-weighted post-contrast axial images are automatically fused with the pre-contrast sequences. B) The tumor region of interest (blue area) and nearby normal brain (purple area) are outlined roughly by hand. C) The enhancing nasal mucosa region is automatically detected with a built-in anatomic atlas (red area) and serves as a threshold for enhancement. D) Tissue that is present on the post-contrast images but not the pre-contrast that is above the enhancement threshold appears in yellow. This includes enhancing tissue such as vasculature, tumor, and superficial structures. Enhancing tumor volume is defined as the green area within the manually-defined blue tumor region of interest.
Figure 3.
Detection of Enhancing Tumor Volume Despite Resection Cavity Collapse.
A) T1-weighted post-contrast axial image showing a resection cavity with rim enhancement. RECIST measurement would be A and Macdonald measurement would be “A * B”. B) T1-weighted post-contrast axial image showing the same patient 3 months postoperatively who had collapse of his resection cavity. RECIST measurement would be “a” and Macdonald measurement would be “a * b”, both of which would be smaller than the measurements from the initial scan above, but this change would be describing only the resection cavity configuration and not the underlying tumor burden.
Figure 4.
Detection of Enhancement that is Obscured by Blood Products.
A) Uncontrasted T1-weighted axial image showing resection cavity blood products (bright on T1). B) T1-weighted post-contrast axial image showing the difficulty in determining residual enhancing tumor. C) Our volumetric analysis is able to detect the obscured enhancing tumor tissue (shown in green). D) T1-weighted post-contrast axial image at 2.5 months later after the blood has resolved verifying the underlying enhancing tumor volume.
Figure 5.
Effect of Inter-observer Differences in Definition of Tumor Volume.
A) Axial T1-weighted post-contrast image showing a limited user-defined tumor region of interest. B) The same axial image now showing a large user-defined tumor region of interest that encompasses the meningeal enhancement. C) While including the meninges increases the enhancing volume, similar trends in changes of volume over time are seen.
Figure 6.
Effect of Different Enhancement Thresholds.
A) Axial T1-weighted post-contrast image after volumetric analysis has been performed which shows in green the detected enhancing tumor volume using a 25% threshold level. B) Detected enhancing tumor volume using a 40% threshold level. C) While increasing the threshold decreases the calculated tumor volume, the volumes across different threshold levels are highly correlated.