Figure 1.
Apomorphine- and methamphetamine-induced rotations in 6-OHDA hemiparkinsonian rats.
The animals were injected with 6-OHDA as described in the text. Rotation was measured after injection of apomorphine (APO) (0.05 mg/kg) (A) or methamphetamine (METH) (2.5 mg/kg) (B).
Table 1.
Effects of 6-OHDA and METH on striatal monoamine levels.
Figure 2.
Differential profiles of transcript levels in saline- and METH-treated 6-OHDA-induced hemiparkinsonian rats.
The Venn diagram shows the distinctiveness and the overlap of genes identified by the four separate comparisons shown in the figure. The rats were treated and euthanized as described in the text. RNA was extracted from striatal tissues obtained from both sides of the brains of saline- and METH-injected hemiparkinsonian rats. Microarray analyses were performed as described in the text. Genes were identified as differently expressed if they showed greater than ±1.7-fold changes at p<0.025.
Table 2.
Partial list of genes showing changes in the DA-depleted striatum of hemiparkinsonian rats.
Table 3.
Partial list of METH-induced changes in the levels of gene transcripts on the intact striatum of hemiparkinsonian rats.
Table 4.
Partial list of genes showing METH-induced changes in the DA-depleted striatum.
Table 5.
METH-induced changes in levels of gene transcripts on the lesioned side of hemiparkinsonian rats.
Table 6.
Effects of METH on striatal expression of transcription factors in hemiparkinsonian rats.
Figure 3.
Effects of DA depletion and METH on striatal expression of Tac1, Tac2, Pdyn, Nts, Nmu and Fst.
The values represent means ± SEM (fold changes in comparison to the SC group) of 6–10 measurements. Statistical analyses were done by ANOVA followed by PLSD. Key to statistics: Key to statistics: *p<0.05, in comparison to the SC group; #p<0.05, in comparison to the SNL group; !p<0.05, in comparison to the MC group; p<0.05, in comparison to the SL group; $p<0.05, in comparison to the MNL group.
Figure 4.
Effects of METH on the expression of Inhba, Acvr1, Pdgf-d, Cox-2, Syt and Synj2bp in DA-depleted striatum.
The values represent means ± SEM (fold changes in comparison to the SC group) of 6–10 measurements. Statistical analyses were done by ANOVA followed by PLSD. Key to statistics: *p<0.05,in comparison to the SC group; #p<0.05, in comparison to the SNL group; !p<0.05, in comparison to the MC group; p<0.05, in comparison to the SL group; $p<0.05, in comparison to the MNL group.