Table 1.
Individual hotspots showing activity of 0.7 cM or higher in female or male meiosis.
Figure 1.
Recombination patterns on mouse chromosome 11.
A. Sex-averaged recombination map of chromosome 11. Recombination events were mapped to an average resolution of 225 Kb in two consecutive rounds. Recombination rates are presented as cM/Mb to adjust for interval size. B. Gene density on chromosome 11 (from ENSEMBL, www.ensembl.org). The X-axis is to scale with 1A. The height of the peaks represents the relative gene density in 1-Mb intervals.
Table 2.
Frequencies of offspring with different number of crossovers on chromosome 11.
Figure 2.
Sex-specific recombination map of chromosome 11.
A. Sex-specific recombination rates averaged over 2-Mb sliding window. B. Fine mapping of recombination activity. The entire chromosome was mapped at 225 Kb resolution and then highly active intervals showing sex-specific rates were mapped further to <50 kb resolution. The recombination rates are expressed as cM to account for these resolution differences. Female, red line above, male, blue line below. C. Expanded view of the region between 16.5-21.5 Mb. Hotspots with higher activity in female (red arrows) or male meiosis (a cluster marked with blue arrow) are shown. The p-values of the difference were determined by Fisher's exact test.
Figure 3.
Sex Specificity of Interference.
A. Coefficient of coincidence (Z) as a function of intercrossover distance in Mb. B. Coefficient of coincidence (Z) as a function of intercrossover distance in µm of synaptonemal length at the pachytene stage of meiosis I. Female, red line; male, blue line.