Table 1.
Classification of the 108 genes of the DM signature according to the RNAi phenotypes of their Drosophila orthologues. The phenoclusters, indicated in bold characters, are described in detail in [20].
Table 2.
The DM signature shares very few genes with other major cancer signatures.
Figure 1.
Predictive power of the DM signature.
Kaplan-Meier analysis using the DM signature shows significant differences in survival of patients from five independents breast cancer datasets.
Figure 2.
Comparative evaluation of the prognostic score of the DM signature.
The prognostic score of the DM signature is compared to those obtained from the CIN [15], Proliferation [11], IGS [14], Hypoxia [9], 70-gene [3], and Wound [5] signatures in the three datasets not used for training. The scores are used to predict outcome at five years. The bars show the areas under the ROC curves (AUC).
Table 3.
Comparison of the performances of the proliferation-based signatures.
Table 4.
Multivariate Cox analysis for the Miller dataset shows that the DM score is predictive of survival independently of other molecular and clinical tumor markers.