Table 1.
Clinical characteristics of patients with liver cirrhosis.
Table 2.
Anti-microbial serological markers in patients with chronic liver diseases and healthy controls.
Figure 1.
Anti-microbial antibody levels in patients with cirrhosis with various levels of severity, as depicted either by Child-Pugh stages (A) or MELD score (B).
A. Individual values are shown by black spots. Mean values with standard error bars are indicated in blue. Cut-off values for positivity are 25 Units for all antibodies. P<0.001 between all groups by ANOVA post hoc Scheffe for ASCA IgA and anti-OMP Plus™ IgA P = NS for ASCA IgG. B. MELD Q1-Q4 represent the groups of patients broken down by quartile: quartile1 patients have the lowest severity up to quartile4, representing patients with the highest level of severity. P<0.001 between all groups by ANOVA post hoc Scheffe for ASCA IgA and anti-OMP Plus™ IgA P = NS for ASCA IgG.
Table 3.
Anti-microbial serological markers in patients with liver cirrhosis according to the disease severity depicted by Child-Pugh stages.
Table 4.
Anti-microbial serological markers in cirrhotic patients according to the absence or presence of ascites.
Table 5.
Logistic regression: Predictive factors for severe bacterial infection in patients with liver cirrhosis.
Figure 2.
Association between Child-Pugh stages (A), presence of ascites (B), co-morbidities (C), seropositivity to ASCA/anti-OMP Plus™ (D) and the development of severe bacterial infection in patients with liver cirrhosis.
Infection-free survival refers to the proportion of patients in the cohort without infection at a given time during the follow-up. A. Patients with Child C stage cirrhosis were at higher risk for developing severe bacterial infections compared to patients with Child A or B disease. B. Patients with ascites were at higher risk for developing severe bacterial infections compared to patients without ascites. C. Patients with co-morbidity were at higher risk for developing severe bacterial infections compared to patients without co-morbidity. D. Patients with multiple seropositivity were at higher risk for developing severe bacterial infections compared to seronegative ones.
Table 6.
Summary of Cox model: factors affecting time to first severe bacterial infection.