Table 1.
Instrument settings for quantitative analysis of HIV protease inhibitors.
Figure 1.
Lopinavir and ritonavir concentrations in an HIV infected child determined by HPLC-UV and by MALDI-triple quadrupole MS.
Pharmacokinetic curve of lopinavir and ritonavir in one HIV infected child determined by HPLC-UV (triangles for lopinavir and crosses for ritonavir), MALDI-triple quadrupole MS (diamonds for lopinavir and circles for ritonavir), and MALDI-triple quadrupole MS when ten additional drugs (10 µM per drug) were spiked to the patient's samples (squares for lopinavir and pluses for ritonavir).
Table 2.
Repeat analysis of PBMC aliquots obtained from HIV-1 infected children.
Table 3.
Plasma and intracellular concentrations of lopinavir and ritonavir in HIV-1 infected children.
Table 4.
Correlations between plasma and intracellular levels, and correlations between the concentrations of the two drugs in HIV-1 infected children.