Table 1.
SNP allele frequencies in the Gambian and Malawian case-control and family trio studies.
Figure 1.
Forest plot of the odds ratios of severe malaria allelic associations at the rs9624472 locus.
Odds ratios of severe malaria associations with the rs9624472 G allele are represented for each study as a grey box with a horizontal line. The mid-point of the line represents the odds ratio and the extreme points of the line represent the 95% CI. The contribution of each study to the meta-analysis is represented by the area of the grey box. The solid vertical line presents an odds-ratio of 1 (no association). The diamond at the bottom presents the overall odds ratio and CI: OR = 1.22 (95% CI: 1.09–1.37), P = 0.001. Cochran's Q-test for heterogeneity on 4 degrees of freedom: P = 0.501.
Figure 2.
Forest plot of the odds ratios of severe malaria allelic associations at the rs5751876 locus.
Odds ratios of severe malaria associations with the rs5751876 C allele are represented for each study as a grey box with a horizontal line. The mid-point of the line represents the odds ratio and the extreme points of the line represent the 95% CI. The contribution of each study to the meta-analysis is represented by the area of the grey box. The solid vertical line presents an odds-ratio of 1 (no association). The diamond at the bottom presents the overall odds ratio and CI: OR = 1.12 (95% CI: 1.02–1.23), P = 0.024. Cochran's Q-test for heterogeneity on 4 degrees of freedom: P = 0.651.
Table 2.
Summary of pooled single-locus associations observed in the ADORA2A gene.
Table 3.
Pooled haplotype-based odds ratios of association with severe malaria in the ADORA2A gene.