Table 1.
Body composition, energy intake and OGTT results after 30 weeks.
Figure 1.
Hepatic and adipose tissue 11β-HSD1.
Data presented as mean ± SEM for lean controls (n = 11, white columns), and diet-induced obese rats after 8 weeks on Western (n = 12, black columns), low carbohydrate (low CHO) (n = 12, grey columns), and moderate carbohydrate (mod CHO) diets (n = 12, striped columns). a) Hepatic 11β-HSD1mRNA levels. b) Hepatic 11β-HSD1 activity. c) Peri-renal adipose 11β-HSD1 mRNA levels. d) Peri-renal adipose 11β-HSD1 activity. The mean of 18S and cyclophilin A was used as internal control (IC) for mRNA data. mRNA transcript levels are expressed as a proportion of the mean values in controls. * p<0.05, ** p<0.01, *** p<0.001 Western vs control. # p<0.05, ## p<0.01 versus Western diet.
Figure 2.
Hepatic and adipose tissue 5α-reductase type 1 and 5β-reductase mRNA and activity.
Data presented as mean ± SEM for lean controls (n = 11, white columns), and diet-induced obese rats after 8 weeks on Western (n = 12, black columns), low carbohydrate (low CHO) (n = 12, grey columns), and moderate carbohydrate (mod CHO) diets (n = 12, striped columns). a) Hepatic 5α-reductase mRNA. b) Hepatic 5β-reductase mRNA. c) Hepatic 5β-reductase activity. d) Peri-renal adipose tissue 5α-reductase mRNA. The mean of 18S and cyclophilin A was used as internal control (IC). mRNA transcript levels are expressed as a proportion of the mean values in controls. ** p<0.01 Western vs control. † p<0.05 mod CHO vs low CHO.
Figure 3.
Hepatic and adipose tissue GRα mRNA.
Data presented as mean ± SEM for lean controls (n = 11, white columns), and diet-induced obese rats after 8 weeks on Western (n = 12, black columns), low carbohydrate (low CHO) (n = 12, grey columns), and moderate carbohydrate (mod CHO) diets (n = 12, striped columns). a) Hepatic GRα mRNA. b) Peri-renal adipose tissue GRα mRNA. The mean of 18S and cyclophilin A was used as internal control (IC). mRNA transcript levels are expressed as a proportion of the mean values in controls. * p<0.05 Western vs control.