Table 1.
Demographic data, CSF and MRI findings in patients with clinically isolated syndrome (CIS).
Figure 1.
Figure shows biomarkers that help to evaluate the risk of multiple sclerosis in patients with clinically isolated syndrome (CIS). MRI = lesion load in T2-weighted magnetic resonance imaging (lesions >3 mm2), OCB = oligoclonal bands in cerebrospinal fluid (CSF), MRZR = MRZ reaction, antibodies to measles, rubella and varicella zoster virus in CSF with two or more AI (antibody indices) ≥1.5. RRMS = relapsing-remitting multiple sclerosis.
Table 2.
Sensitivity, specificity, positive (PPV) and negative (NPV) predictive value in percent (exact 95% confidence interval in brackets) for CSF and MRI parameters regarding conversion of clinically isolated syndrome to definite multiple sclerosis.