Figure 1.
Map of the old world showing the sampling locations for the populations here examined.
Each pie represents the percentage of the slow (white), intermediate (grey), and fast (black) acetylators in the extended panel, inferred from genotype data as described in Materials and Methods. Inset: map showing the frequency of slow (white) and fast (black) haplotypes as inferred based on biochemical data [6].
Table 1.
Summary statistics of NAT2 diversity in the continental samples of the resequencing panel.
Table 2.
Relative haplotype frequencies in 12 population samples.
Figure 2.
Median-joining networks of NAT2 haplotypes in the 12 populations of the extended panel.
The relationships between the 17 haplotypes found in the pool of the 12 populations are displayed by the network on top, with nodes of fixed size. Vectors representing each mutation are oriented as shown on top right (e.g. the vector 341 connects haplotypes which differ only at the position 341). Nodes representing fast and slow haplotypes are color-coded in black and grey, respectively. Networks specific for each population are displayed using the same skeleton and omitting only unnecessary links. Node size is proportional to the number of observations. Note that three main features of the overall network are necessary to explain the haplotypic composition of all but two populations (the left-hand “cube” leading to *5B and the right-hand “planes” leading to *7B and *6A), and that in most cases the median vectors of these structures are actually found. In all graphs the ancestral haplotype *4 is identified by a lozenge.
Table 3.
Measures of intra- and inter-population diversity by using different inter-haplotypic distances.
Table 4.
Test of equality of frequency of 5 NAT2 haplotype series among three major modes of subsistence.