Table 1.
Hemodynamics and blood gas data at the point of maximum hemodilution (n = 7 in each group)
Figure 1.
The changes of calculated arterial oxygen content during acute isovolemic hemodilution with Oxycyte® or albumin.
Hemodilution causes a progressive decrease in Hct level. The arterial oxygen content decreases in an inverse proportion to the levels of Hct during hemodilution with either albumin or Oxycyte®. However, the arterial oxygen content is maintained at a significantly higher level during hemodilution with the Oxycyte® group than in hemodilution with the albumin group. Open bar: acute isovolemic hemodilution with albumin; Shaded bar: acute isovolemic hemodilution with Oxycyte®.
Figure 2.
The changes of regional cerebral blood flow during acute isovolemic hemodilution with Oxycyte® or albumin.
Hemodilution causes a progressive decrease in Hct level. The regional cerebral blood flow increases in an inverse proportion to the levels of Hct and doubles from baseline when Hct level is lower than 10% during hemodilution with albumin. During hemodilution with Oxycyte®, the regional cerebral blood flow increases to 150% of baseline when the Hct is between 10–20% and then decreases to about 120% of baseline when the Hct decreased to below 10%. Open bar: acute isovolemic hemodilution with albumin; Shaded bar: acute isovolemic hemodilution with Oxycyte®.
Figure 3.
The changes of regional cerebral blood flow during acute isovolemic hemodilution with Oxycyte® or albumin.
Hemodilution causes a progressive decrease in arterial oxygen content level. The regional cerebral blood flow continues to increase in an inverse proportion to the levels of arterial oxygen content during hemodilution with albumin. During hemodilution with Oxycyte®, the regional cerebral blood flow increases significantly less when arterial oxygen content decreased to below 10 dl/ml. Open bar: acute isovolemic hemodilution with albumin; Shaded bar: acute isovolemic hemodilution with Oxycyte®.