Table 1.
Clinical and Demographic Characteristics of the Study Cohort At Study Entry.
Figure 1.
Higher absolute CD4+ T cell counts in HSV-2+/HIV-1+ subjects independent of HIV-1 viral load.
The open blue diamonds represent the CD4+ T cell counts, and the open red dots represent HIV-1 viral load over time for persons co-infected with HSV-2 at the time of diagnosis with an early HIV-1 infection. The solid blue diamonds represent the CD4+ T cell counts, and the solid red dots HIV-1 viral load, for those HSV-2 negative at the time of early HIV-1 infection. Observations were right censored at the time anti-retroviral therapy was initiated, which occurred at approximately a CD4+ T cell count of 350 cells/µL.
Figure 2.
HSV-2 acquisition after HIV-1 acquisition is not associated with subsequent differences in CD4+ T cell counts or HIV-1 viral load.
The open blue diamonds represent the CD4+ T cell counts, and the open red dots represent HIV-1 viral load, over time for persons testing positive for HSV-2 at 1 year after study enrollment. The solid blue diamonds represent the CD4+ T cell counts, and the solid red dots HIV-1 viral load, for those HSV-2 negative at 1 year after study enrollment. Forty-seven of the 85 persons who tested HSV-2 negative at study entry were re-tested. Observations were right censored at the time persons initiated anti-retroviral therapy, which was initiated at approximately a CD4+ T cell count of 350 cells/µL.
Figure 3.
No Difference in Total CD4+ T Cell Phenotypes by HSV-2 Status.
Red symbolizes those persons who test positive for HSV-2 at study entry and are HIV-1 co-infected. Green are those persons who tested negative for HSV-2 at study entry and are infected with HIV-1 only. ‘27’ represents CD27, and ‘RA’ represents CD45RA, which were used to define differentiation stages of the total CD4+ T cell pool.