Table 1.
Confirmed associations of genetic variants in inflammation-associated genes and disease.
Figure 1.
Development of an immune response.
Depicted is a schematic representation of an immune response to a generic pathogenic insult. The phases of immune responses (described in Table 2) are shown in bold. Additional aspects not shown are the involvement of secondary lymphoid tissues for initial T cell and B cell activation by dendritic cells that migrate from the site of inflammation to lymph nodes and other secondary lymphoid structures. The resolution of immune responses, immunological memory, and homeostasis are also not depicted.
Table 2.
Phases of immune response.
Figure 2.
Inflammation subpathways involved in the response to danger signal.
The concerted action of multiple functional subpathways in the initial response of a macrophage to bacteria or virus is depicted. Solid arrows indicate signaling events and dashed arrows stimulated production of proteins and other inflammatory mediators (including autocrine/paracrine responses of the macrophage to the released molecules).
Table 3.
Pathways and proteins associated with immune response phases.
Table 4.
Primary subpathways in inflammation panel.