Lower Respiratory Tract Infection Induced by a Genetically Modified Picornavirus in Its Natural Murine Host
Figure 1
Differences between attenuated mengovirus and HRV in the kinetics of lung viral titers.
Mice received intranasal inoculations of 106 PFU of attenuated mengovirus, vMC0 [A (n = 7 mice per group), B (n = 6 mice per group)], or 5×106 PFU of HRV-A01a (C; n = 4 mice per group). Lungs were harvested at the indicated times, and viral titers in lung homogenates were determined by plaque assays. Data are the total amount of virus present in the lung homogenates (virus concentrations were multiplied by lung homogenate volumes). No virus was detected in lungs from vehicle-inoculated mice. Data are presented as box plots. For one HRV-A01a-inoculated mouse at 3 h postinoculation, a value of 1 PFU was assigned for graphing purposes because virus was undetectable. ND, not detectable.