Temporal transcriptomic profiling of pulmonary thromboembolism reveals persistent NETosis- and ferroptosis-associated gene signatures and enhanced thrombolysis with adjunctive DNase I
Fig 6
Changes and improvement rates of various indicators following rt-PA monotherapy and rt-PA + DNase I combination therapy on day 7 after PTE modeling.
(A) Collagen fiber area fraction. (B) PAT. (C) SpO2. (D) LVEF. (E) LVFS. (F) MPO-DNA. (G) vWF. (H) BNP. (I) PAI-1. (J) t-PA. (K) VEGF. n = 6 biologically independent animals per treatment group. *, P < 0.05; **, P < 0.01; ***, P < 0.001.