Temporal transcriptomic profiling of pulmonary thromboembolism reveals persistent NETosis- and ferroptosis-associated gene signatures and enhanced thrombolysis with adjunctive DNase I
Fig 5
qRT-PCR validation of common NETs/ferroptosis-related and temporal-specific DEGs after PTE.
(A) Common NETs/ferroptosis-related DEGs at various time points post-PTE modeling. (B) Specific DEGs at day 1 post-PTE modeling. (C) Specific DEGs at day 3 post-PTE modeling. (D) Specific DEGs at day 7 post-PTE modeling. (E) Specific DEGs at day 14 post-PTE modeling. n = 6 biologically independent animals per group/time point. *, P < 0.05; **, P < 0.01; ***, P < 0.001.