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Temporal transcriptomic profiling of pulmonary thromboembolism reveals persistent NETosis- and ferroptosis-associated gene signatures and enhanced thrombolysis with adjunctive DNase I

Fig 2

Dynamic changes in serological indicators before and after PTE modeling.

(A) MPO-DNA. (B) vWF. (C) BNP. (D) D-dimer. (E) PAI-1. (F) t-PA. (G) VEGF. (H) HSP-47. n = 6 biologically independent animals per group/time point. *, P < 0.05; **, P < 0.01; ***, P < 0.001.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0349853.g002