Comparative genomics of human brain and immune gene preservation across species
Table 4
Contingency tables and Fisher’s exact test results for three comparisons: (1) the subsets of “wide 10” genes (genes highly expressed in at least 10 tissues) in and
, (2) the subsets of “narrow 10” genes (genes highly expressed in less than 10 tissues) in
and
, and (3) the subsets of “tissue specific” genes, the genes highly expressed exclusively in brain tissues in
and genes highly expressed exclusively in immune-related tissues in
. Positive cases are primate-specific genes, while negative cases are genes that are not primate specific. A p-value less than 0.01 are marked with two asterisks (**), indicating a more statistically significant difference. An odds ratio less than 1 suggests the group in
is less likely to be primate specific compared to the group in
. The union of “wide 10” and “narrow 10” genes corresponds to the complete gene sets (1019 and 586) reported in Table 2, where results for the full sets are shown. This separation allows assessment of whether statistical significance observed in the full gene sets is driven primarily by the “wide 10,” “narrow 10”, or “tissue specific” subset.