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Comparative genomics of human brain and immune gene preservation across species

Fig 2

Statistical comparisons and gene distribution summary.

(A) Cohen’s h values for pairwise comparisons between and the other two groups: and . Primate Specific Ratios are calculated as in Table 1. A higher absolute Cohen’s h indicates a greater difference in ratios between the two compared groups. Green bar represents , orange bar represents , and blue bars represent . (B) Results of Fisher’s exact tests for pairwise comparisons between each of , , and and each control group ( and ), together with the comparison between and . Primate Specific Ratios are calculated as in Table 1. Statistical significance is denoted by asterisks. Results with p-values less than 0.01 are indicated by two asterisks (**), results with p-values less than 0.05 are indicated by one asterisk (*), and all other results are marked as ns. Green bar represents , orange bar represents , blue bar represents , gray bars represent , and purple bars represent . (C) The number of tissues corresponding to each quantile for the brain genes and immune-related genes. Green bars represent , orange bars represent , and gray bars represent all genes that have at least one highly expressed tissue in Human Protein Atlas [32,33]. (D) The number and ratio of genes highly expressed specifically in brain tissues or immune-related tissues, out of 1019 brain genes and 586 immune-related genes, respectively.

doi: https://doi.org/10.1371/journal.pone.0348713.g002