Artemether ameliorates type 1 diabetic liver injury alongside the associated defects in mitochondrial ultrastructure and central carbon metabolism
Fig 5
Artemether prevented hepatic fat mobilization and fatty acid activation, and regulated triglycerides in T1DM mice to normal levels.
(A) Serum TG levels in the mice. (B) Hepatic TG levels in the mice. (C) mRNA expression levels of Atgl, Fatp2 and Acsl1 in the liver. (D-F) Western blotting for ATGL and HSL in the liver. (G-J) Western blotting for FATP2, ACSS3 and ACSM2A in the liver. ALDH2 serves as an internal reference. The results were indicated as the means ± SEMs(n = 4-8), *p < 0.05, * *p < 0.01 and ***p < 0.001 vs. Control group; #p < 0.05, ##p < 0.01 and ###p < 0.001 vs. the T1D group.